Nginx server is used by wordpress itself. We solved Image upload issue in wordpress with nginx. you can use following code.

Image upload issue in wordpress with nginx

Please Use the following code:


location ~ ^.+\.(html|jpg|jpeg|gif|png|ico|css|zip|tgz|gz|rar|bz2|doc|xls|exe|pdf|ppt|txt|tar|mid|midi|wav|bmp|rtf|js)$ {
root /usr/share/nginx/html/wordpressmu;
rewrite ^/.*(/wp-admin/.*\.(html|jpg|jpeg|gif|png|ico|css|zip|tgz|gz|rar|bz2|doc|xls|exe|pdf|ppt|txt|tar|mid|midi|wav|bmp|rtf|js))$ $1 last;
rewrite ^/.*(/wp-includes/.*\.(html|jpg|jpeg|gif|png|ico|css|zip|tgz|gz|rar|bz2|doc|xls|exe|pdf|ppt|txt|tar|mid|midi|wav|bmp|rtf|js))$ $1 last;
rewrite ^/.*(/wp-content/themes/.*\.(html|jpg|jpeg|gif|png|ico|css|zip|tgz|gz|rar|bz2|doc|xls|exe|pdf|ppt|txt|tar|mid|midi|wav|bmp|rtf|js))$ $1 last;
rewrite ^/.*(/wp-content/.*\.(html|jpg|jpeg|gif|png|ico|css|zip|tgz|gz|rar|bz2|doc|xls|exe|pdf|ppt|txt|tar|mid|midi|wav|bmp|rtf|js))$ $1 last;
rewrite ^.*/files/(.*(html|jpg|jpeg|gif|png|ico|css|zip|tgz|gz|rar|bz2|doc|xls|exe|pdf|ppt|txt|tar|mid|midi|wav|bmp|rtf|js))$ /wordpress/wp-content/blogs.php?file=$1 last;

expires 10d;
break;
}

Written by WPAPI

My name is Purab Kharat, Here is my Personal Blog: digcms.com. Work as an Senior Technical Lead at Smartsourcing Global Pvt Ltd in Princeton, NJ, USA. I contributor of many wordpress plugins and Drupal Modules. I am core developer of Drupal. Connect to purab on LinkedIn or Follow @purab on Twitter or Follow me on Google+ or Write Mail to purabdk@gmail.com or Chat with me on Skype : purabdk

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